Why Zika virus caused most harmful brain damage to Brazilian newborns

Due to Zika virus, more than 1,600 babies were born in Brazil with microcephaly, or abnormally small heads, from September 2015 through April 2016. The epidemic took health professionals by surprise because the virus had been known since 1947 and was not linked to birth defects. As scientists scrambled to figure out what was going on, one fact stood out: […]

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Dangerous skin tumor now has treatment guidelines

It starts as a yellow or shiny bump on the eyelids, face or body that grows and doesn’t go away, unlike a pimple. The bump is sebaceous carcinoma, a cancer of the oil glands diagnosed in thousands of patients in the U.S. every year. If not removed and treated promptly, it can spread to other organs and cause grave harm […]

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Technology that unblocks children’s airways

A new technology to unblock and remove secretions from the respiratory tract of children has been developed as part of a collaboration between researchers at Ben-Gurion University of the Negev (BGU) and its affiliated Soroka University Medical Center, Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati (UC). The new device will be beneficial for treatment of children suffering […]

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NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis

In this study, the research team investigated NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies that had been subjected to whole exome sequencing. One line, SJG6, was found to have truncating mutations in both NOTCH1 alleles, resulting in loss of NOTCH1 expression. Overexpression of the NOTCH1 intracellular domain in SJG6 cells promoted cell adhesion and differentiation, while suppressing proliferation, […]

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Targeted therapy better for repeat kidney cancer patients than FDA-approved counterpart

Kidney cancer patients who had already tried two or three different treatments had improved chances of preventing cancer progression with an experimental drug called tivozanib compared to an alternative approved by the U.S. Food and Drug Administration, according to a City of Hope-led study. “This agent has shown in clinical trials to be effective in delaying cancer growth beyond established […]

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Fitness consultations in oncology care motivate child cancer survivors to be more active

Just one exercise physiology consultation is enough to improve motivation and exercise levels among most child cancer survivors, a UNSW Sydney study has found. Almost three quarters of child cancer survivors increased their general exercise after just one consultation with an exercise physiologist, a UNSW Sydney study has found. The sessions were also motivational, with nine out of 10 kids […]

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Developing a new AI breast cancer diagnostic tool

Scientists are developing a new way to identify the unique chemical ‘fingerprints’ for different types of breast cancers. These new chemical footprints will be used to train AI software—creating a new tool for rapid and accurate diagnosis of breast cancers. The team of researchers from Lancaster University and Airedale NHS Foundation Trust are using a specialised chemical analytical technique called […]

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New technique visually depicts how cancer cells grow and spread in colon tissue

Duke Cancer Institute researchers have observed how stem cell mutations quietly arise and spread throughout a widening field of the colon until they eventually predominate and become a malignancy. Using an innovative modeling system in mice, the researchers visually tagged colon cancer mutations by causing stem cells to glow. Mutations found in colon cancer were then visualized in the animals, […]

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Activation by breakdown: Identifying molecular mechanisms that underlie immune response

LMU researchers report that a central component of the innate immune response is activated by two short RNAs which are produced by site-specific cleavage of a precursor RNA molecule—and both derivatives are generated by the same enzyme. The innate immune system can be thought of as the frontline in the body’s fight against invasive pathogens. Cells possess specialized receptors that […]

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